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纤溶酶原激活物抑制剂 1(ＰＡＩ 1)可以促进动脉粥样硬化 (ＡＳ)的发展。本实验构建ＰＡＩ 1反义ＲＮＡ重组质粒 ,将其转导入离体培养的主动脉内皮细胞(ＥＣ)中 ,观察其对ＰＡＩ 1表达的作用及对血小板源生长因子 (ＰＤＧＦ)的影响。体外培养猪主动脉内皮细胞 ,免疫组化显示Ｃ
Plasminogen Activator Inhibitor 1 (PAI 1) promotes the development of atherosclerosis (AS). PAI 1 antisense RNA recombinant plasmids were constructed and transfected into cultured aortic endothelial cells (ECs). The effect of PAI 1 on the expression of PAI 1 and its effect on platelet-derived growth factor (PDGF) were investigated. In vitro culture of porcine aortic endothelial cells, immunohistochemistry C