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目的研究五倍子液经EIS注射后凝血和纤溶的变化。方法对9例均有1次以上食管曲张静脉破裂出血史的肝硬化门脉高压患者经EIS注射75％五倍子液，于注射前、注射后30min和120min测定BPC、PT、KPTT、TT、Fg、vWF：Ag、Ⅷ：C、GMP－140、D－D和FPA。结果BPC、PT、KPTT、TT、Fg、vWF：Ag和Ⅷ：C无显著性变化（P＞0．05），而GMP－140、D－D和FPA在注射后30min明显升高（P＜0．05），120min后恢复至注射前水平。结论（D—D和FPA升高表明五倍子液能短暂激发凝血纤溶系统，而这种激发仅限于注射局部，并没有激发全身性凝血纤溶系统引起DIC的发生。
Objective To study the changes of coagulation and fibrinolysis of gallnut fluid after EIS injection. Methods 9 patients with cirrhotic portal hypertension who had more than one history of esophageal variceal hemorrhage were injected with 75% gallic fluid by EIS. BPC, PT, KPTT, TT, and Fg were measured before and 30 min and 120 min after injection. vWF: Ag, VIII: C, GMP-140, D-D and FPA. Results There were no significant changes in BPC, PT, KPTT, TT, Fg, vWF:Ag and VIII:C (P>0.05), while GMP-140, D-D and FPA were significantly elevated at 30 min after injection (P< 0.05), return to pre-injection level after 120 min. Conclusions (D-D and FPA elevations suggest that gallnut fluid can transiently stimulate the coagulation and fibrinolytic system, and this excitation is limited to local injections and does not stimulate the systemic coagulation and fibrinolysis system to cause DIC.