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Aim: As the quality of environment becomes more and more deteriorated, incidence of cancer rises steadily as a result of accumulation of carcinogenetic risk. It is impossible for people to keep away from carcinogenetic substances completely. therefore screening of edible antimutagens or anticarcinogens. from natural food such as fruit or vegetable or herbs to offset the carcinogenetic effect of carcinogens is especially important for cancer prevention. According to the traditional chinese medical theory and practice. food and medicine are equally capable for the treatment and prevention of diseases. The present study is aimed to find natural edible antimutagenic substances to improve the health improving quality of everyday food. Methods: Mutational and antimutational rapid synchronous test was employed to examine the reaction of water melon. sweet melon, strawberry, baby soybean, and baby helan bean towards the mutagenesis induced by Mitomicy (MMC) in esogenic strain GY5027. Results: Water melon. sweet melon. and strawberry inhibited mutagenesis induced by MMC in GY5027, but baby soybean and baby helan bean showed no effect. Conclusion: Water melon, sweet melon, and strawberry may have antimutagenic ability, their health improving role should be stressed in everyday life.