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目的研究瘦素受体及雌激素受体在肺癌及肺正常组织中的表达差别。方法对肺癌组织及肺正常组织各30例标本行免疫组化染色法,检测瘦素受体和雌激素受体的表达,并比较这两种受体在肺癌及肺正常组织中表达的差异以及在不同类型肺癌中表达的差异,探讨其与肺癌之间的关系。结果 30例肺正常组织标本中瘦素受体及雌激素受体的阳性表达率分别为26.67%(8/30)及0%(0/30)。30例肺癌组织标本中瘦素受体及雌激素受体的阳性表达率分别为73.33%(22/30)及63.33%(19/30),均明显高于正常组(P﹤0.05);瘦素受体及雌激素受体在肺正常标本中的阳性表达率差异有统计学意义(P﹤0.05),而在肺癌组织标本中差异无统计学意义(P﹥0.05)。肺癌标本中瘦素受体及雌激素受体的表达在性别和肺癌类型差异无统计学意义(P﹥0.05)。结论瘦素受体及雌激素受体在肺癌组织中均呈现高表达,与肺癌的发生可能存在一定相关性。
Objective To study the expression differences of leptin receptor and estrogen receptor in lung cancer and normal lung tissues. Methods Immunohistochemistry was used to detect the expression of leptin receptor and estrogen receptor in 30 specimens of lung cancer tissues and normal lung tissues. The expression of these receptors in lung cancer and normal lung tissue were compared. In different types of lung cancer expression differences, explore its relationship with lung cancer. Results The positive expression rates of leptin receptor and estrogen receptor in 30 normal lung tissues were 26.67% (8/30) and 0% (0/30), respectively. The positive rates of leptin receptor and estrogen receptor in lung cancer specimens from patients with lung cancer were 73.33% (22/30) and 63.33% (19/30), respectively, which were significantly higher than those in normal controls (P <0.05) There were significant differences in the positive expression rates of the hormone receptor and estrogen receptor in the normal lung specimens (P <0.05), but not in the lung tissue specimens (P> 0.05). The expression of leptin receptor and estrogen receptor in lung cancer specimens showed no significant difference between genders and lung cancer types (P> 0.05). Conclusion The leptin receptor and estrogen receptor are highly expressed in lung cancer tissues, which may be related to the occurrence of lung cancer.