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实验用18只家兔分为三组(每组6只):①缺血/再灌注组(R 组)—结扎冠状动脉左室支40 min 后松结再灌注30 min。②缺血/再灌注十纳洛酮(nalo×one,Nal)组(R+Nal 组)—再灌注前5 min 静脉注射 Nal(3mg/kg)。③假手术对照组(C 组)。观察了心肌丙二醛(MDA)、钙、钾含量变化,结果:R 组缺血/再灌注区心肌 MDA 和钙含量大大高于 C 组(P<0.01,P<0.01),心肌钾含量显著低于 C 组(P<0.01)。R+Nal 组缺血/再灌注区心肌 MDA 和钙含量均低于 R 组缺血/再灌注区(P<0.05,P<0.01),心肌钾含量则高于 R 组缺血/再灌注区(P<0.05)。这些结果表明 Nal 对缺血/再灌注心肌具有保护作用。
Eighteen rabbits were divided into three groups (six in each group): 1 Ischemia/reperfusion group (R group)—The left ventricle branch of the coronary artery was ligated for 40 min and loosened for 30 min. 2 Ischemia/reperfusion naloxone (nalo×one, Nal) group (R+Nal group)—Nal (3 mg/kg) was injected intravenously 5 min before reperfusion. 3 sham control group (group C). Changes in myocardial malondialdehyde (MDA), calcium, and potassium levels were observed. Results: Myocardial MDA and calcium levels in the R group were significantly higher than those in the C group (P<0.01, P<0.01). Lower than group C (P<0.01). The content of MDA and calcium in the ischemic/reperfusion zone of R+Nal group was lower than that in R group (P<0.05, P<0.01). The potassium content in R+Nal group was higher than that of R group in ischemia/reperfusion zone. (P<0.05). These results indicate that Nal has a protective effect on ischemia/reperfusion myocardium.