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目的比较芬太尼、依托咪酯联合用药与单纯用依托咪酯在无痛人流术中的安全性及有效性。方法 ASAⅠ～Ⅱ级人工流产患者60例,随机分为对照组和观察组,每组30例,对照组单纯使用依托咪酯,观察组用芬太尼联合依托咪酯。观察并记录诱导前、术中、术后两组患者SBP、DBP、HR、SpO2的变化和两组患者的不良反应及患者满意度。结果观察组诱导期依托咪酯用量明显少于对照组(P<0.01)。观察组术中SBP和DBP与诱导前相比略有下降,但与对照组比较差异无显著性。SBP、DBP、HR及SpO2两组间比较差异无显著性。下腹痛和患者满意度观察组与对照组比较差异有显著性(P<0.05)。肌阵挛、呼吸抑制和恶心呕吐两组间比较差异无显著性(P>0.05)。观察组麻醉镇痛效果和患者满意度明显优于对照组。结论芬太尼联合依托咪酯用于人流产手术的麻醉安全有效,镇痛效果好。
Objective To compare the safety and efficacy of fentanyl, etomidate and etomidate in painless abortion. Methods Sixty ASA Ⅰ ~ Ⅱ induced abortion patients were randomly divided into control group and observation group, 30 cases in each group. The control group was given etomidate alone, while the observation group was given fentanyl combined with etomidate. The change of SBP, DBP, HR, SpO2 and the adverse reactions and patient satisfaction of the two groups before and after induction were observed and recorded. Results The induction of etomidate in the observation group was significantly less than that of the control group (P <0.01). The SBP and DBP in the observation group decreased slightly compared with before induction, but there was no significant difference compared with the control group. SBP, DBP, HR and SpO2 no significant difference between the two groups. Lower abdominal pain and patient satisfaction observation group compared with the control group, the difference was significant (P <0.05). Myoclonus, respiratory depression and nausea and vomiting no significant difference between the two groups (P> 0.05). Observation group anesthesia analgesic effect and patient satisfaction was significantly better than the control group. Conclusions Fentanyl combined with etomidate is safe and effective for anesthesia in human abortion and has good analgesic effect.