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从Salvia miltiorrhiza Bunge根中得到的丹参是传统的中草药,已用于治疗冠心病.晚近,发现其乙醇提出物丹参酮Ⅱ-A磺酸盐能有效地抗心绞痛.由于钙内流阻滞剂,如异搏停与硫氮(艹卓)酮已应用于临床治疗心绞痛 ,故丹参酮的抗心绞痛作用可能是由钙内流的阻滞所致.通过应用下列三个方法,在离体豚鼠乳头肌观察了丹参酮的钙内流阻滞作用:
Salvia miltiorrhiza Bunge root derived Salvia is a traditional Chinese herbal medicine, has been used for the treatment of coronary heart disease. Recently, it was found that ethanol extract tanshinone II-A sulfonate can effectively resist angina. Because of calcium influx blockers, such as Both eclampsia and thiazepine have been used in the clinical treatment of angina pectoris. Therefore, the anti-angina effect of tanshinone may be caused by the block of calcium influx. By using the following three methods, the guinea pig papillary muscles were observed. The calcium influx blockade effect of tanshinone: