Asymmetric total syntheses of (+)-goniopypyrone and (+)-9-deoxygoniopypyrone

• 出 处: Chinese Journal of Chemistry
• 发表日期: 1996年02期
• 关键词: steps asymmetric catalyzed eleven hexane magnesium isopropyl aldehyde inexpensiv

Asymmetric total syntheses of (+)-goniopypyrone (1) and (+)-deoxygoniopypyrone (2) from methyl cinnamate (7) via (DHQ)2-PHAL-OsO4 catalyzed asymmetric dihydroxylation and highly stereoselective 2-furylcopper addition in eight steps and eleven steps with overall yield of 20% and 13%,respectively,are described.