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I型干扰素联合GM-CSF诱导人外周血单核细胞(PBMC)分化产生的树突状细胞(DC)被称为IFN-DC。IFN-DC在细胞形态、表型特征和功能上均有别于GM-CSF联合IL-4诱导PBMC产生的IL-4-DC。IFN-DC呈现出强于IL-4-DC的抗原摄取提呈能力和强大的促CD8+T淋巴细胞和记忆T淋巴细胞增殖能力,同时IFN-DC既有成熟又有不成熟DC的趋化特征、诱导Th1极化能力以及强大的活化抗原特异性CD8+细胞毒T细胞(CTL)的能力;IFN-DC还可通过肿瘤坏死因子相关的凋亡诱导蛋白(TRAIL)诱导靶细胞的凋亡,抑制CD4+CD25+Foxp3+Treg。
Dendritic cells (DCs) produced by type I interferons in combination with GM-CSF to induce differentiation of human peripheral blood mononuclear cells (PBMCs) are called IFN-DCs. IFN-DC is different from IL-4-DC induced by GM-CSF and IL-4 in PBMC in morphology, phenotype and function. IFN-DC showed stronger ability of antigen uptake than IL-4-DC and strong ability of promoting CD8 + T lymphocyte and memory T lymphocyte proliferation, meanwhile IFN-DC had chemotaxis of both mature and immature DC The ability to induce Th1 polarization and the powerful activated antigen-specific CD8 + cytotoxic T cells (CTL). IFN-DC also induced the apoptosis of target cells through tumor necrosis factor-related apoptosis-inducing protein (TRAIL) Inhibit CD4 + CD25 + Foxp3 + Tregs.