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探讨共刺激分子B7-H1在人结肠直肠癌组织中的表达及其意义。运用免疫组织化学SP法检测B7-H1分子在60例结肠直肠癌组织中的表达,并对其表达水平与结肠直肠癌临床病理参数之间的关系进行相关性分析。结果显示,B7-H1分子在结肠直肠癌组织中的阳性表达显著高于正常结肠直肠组织(P<0.01);B7-H1在结肠直肠癌组织中阳性表达率为60%,与患者性别、年龄、肿瘤组织的类型、分级和分期无关(P>0.05),而与淋巴结是否转移显著相关(P<0.01)。B7-H1在结肠直肠癌组织中的高表达,可能在肿瘤的发生、发展中起到一定作用,有望成为结肠直肠癌免疫治疗的一个新靶点。
To investigate the expression of costimulatory molecule B7-H1 in human colorectal cancer and its significance. Immunohistochemical SP method was used to detect the expression of B7-H1 in 60 cases of colorectal cancer tissues. The correlation between the expression of B7-H1 and the clinicopathological parameters of colorectal cancer was analyzed. The positive expression rate of B7-H1 in colorectal cancer tissues was significantly higher than that in normal colorectal tissues (P <0.01). The positive expression rate of B7-H1 in colorectal cancer tissues was 60% , Tumor type, grade and stage (P> 0.05) but not lymph node metastasis (P <0.01). The high expression of B7-H1 in colorectal cancer tissues may play a role in the occurrence and development of tumors, which is expected to become a new target of colorectal cancer immunotherapy.