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应用羟丙甲纤维素、乙基纤维素为主要骨架材料，掺入适量的乳糖和海藻酸钠调节释药速率和片剂的重量，１５％ ＰＶＰ乙醇液作粘合剂，采用湿颗粒间接压片法制得了日服一次的盐酸地尔硫卓艹缓释片。采用均匀设计结合综合评分方法，经多元线性回归和多元逐步回归处理，建立了处方组成因素等对释药速率影响的多元定量关系式。缓释片中的药物释放基本符合一级方程。照相法描述了缓释片的体外膨胀行为。
Hypromellose and ethyl cellulose were used as the main skeleton materials. The proper dosage of lactose and sodium alginate were mixed to adjust the drug release rate and the weight of the tablets. 15% PVP ethanol solution was used as the binder, and the wet granule indirect pressure Film legal system was made once daily Diltiazem Hydrochloride sustained-release tablets. By means of uniform design and comprehensive score method, multivariate linear regression and multivariate stepwise regression were used to establish the multivariate quantitative relationship of the factors that influenced the drug release rate. Sustained release tablets in the drug release basically in line with the first equation. Photographic methods describe the in vitro expansion behavior of sustained-release tablets.