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糖尿病是威胁人类健康的重要疾病之一,发病率在我国逐年上升,给家庭和社会带来沉重负担。胰腺是维持体内血糖水平衡定的最重要的器官,尤其是胰岛的生理功能对维持机体血糖的稳定发挥着至关重要的作用。各种刺激导致胰岛损伤、胰岛β细胞数量减少、胰岛素分泌缺陷以及胰岛素抵抗,进而引发糖尿病。通过研究胰岛生理与糖尿病的关系,有助于进一步了解糖尿病的发病机制以及研究治疗方案。
Diabetes is one of the most important diseases threatening human health. The incidence is rising year by year in our country, which brings heavy burden to families and society. The pancreas is the most important organ for maintaining the blood glucose level in the body. In particular, the physiological function of islets plays a crucial role in maintaining the stability of the body’s blood sugar. Various stimuli lead to islet injury, decreased islet beta cell count, insulin secretion defects, and insulin resistance, which in turn triggers diabetes. By studying the relationship between islet physiology and diabetes, help to further understand the pathogenesis of diabetes and research and treatment programs.