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应用SP免疫组化方法检测86例甲状腺癌、20例甲状腺腺瘤和25例癌旁正常甲状腺组织中肿瘤转移抑制基因NM~23的蛋白表达。结果:NM~23在三者中阳性率分别为73.3％、40.0％和16.0％(P<0.005);NM~23基因表达率与甲状腺癌是否伴有颈淋巴结转移无关,而与癌细胞分化程度、肿瘤包膜完整性和肿瘤临床病理分期有密切关系(P<0.05)。此外,NM~23阳性组平均生存时间明显长于阴性组(P<0.01)。结果提示:NM~23基因在甲状腺癌发展过程中具有重要作用,检测NM~23蛋白可作为评估其预后的一个有价值的指标。
Immunohistochemical SP method was used to detect the expression of tumor metastasis suppressor gene NM-23 in 86 cases of thyroid cancer, 20 cases of thyroid adenoma and 25 cases of normal thyroid tissue adjacent to cancer. Results: The positive rates of NM-23 in the three were 73.3%, 40.0%, and 16.0%, respectively (P<0.005). The expression of NM-23 was not related to the involvement of cervical lymph node metastasis in thyroid cancer, but to the degree of differentiation of cancer cells. There was a close relationship between tumor capsule integrity and tumor clinical pathological stage (P<0.05). In addition, the average survival time of the NM~23 positive group was significantly longer than that of the negative group (P<0.01). The results suggest that the NM-23 gene plays an important role in the development of thyroid cancer. The detection of NM-23 protein can be used as a valuable index to evaluate its prognosis.