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应用ＡＢＣ免疫组化染色法，研究Ｐ５３突变蛋白表达与胃癌周围淋巴结及远处器官转移的关系。结果表明：Ｐ５３在胃癌中表达率为５４．８％（３４／６２）。Ｐ５３表达在未发生转移的胃癌中为５０％（７／１４），在已发生癌周淋巴结转移的胃癌中为５６％（２７／４８），两组无显著性差异（Ｐ＞０．０５），但在已发生远处器官转移的胃癌中Ｐ５３表达率为７２．７％（８／１１），显著高于前两组（Ｐ＜０．０１）。提示该基因表达与胃癌远处器官转移及不良的预后有关。
ABC immunohistochemical staining was used to study the relationship between P53 mutant protein expression and lymph node metastasis in gastric cancer and distant organ metastasis. The results showed that the expression rate of P53 in gastric cancer was 54.8% (34/62). P53 expression was 50% (7/14) in gastric cancer without metastasis and 56% (27/48) in gastric cancer with metastatic lymph node metastasis. There was no significant difference between the two groups (P>0.05). However, the rate of P53 expression in gastric cancer with distant organ metastasis was 72.7% (8/11), which was significantly higher than that of the former two groups (P<0.01). It is suggested that the expression of this gene is related to distant gastric cancer metastasis and poor prognosis.