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目的:观察低分子肝素(LMWH)对不稳定型心绞痛((UAP)的临床症状、心电图、血脂以及内皮素(ET)的影响。方法:前瞻性地将84例UAP患者随机分为两组:对照组使用硝酸甘油、倍他乐克、阿司匹林等药物;治疗组(LMWH组)在上述治疗基础上加用LMWH(速避凝)。治疗前后调查临床症状以及心电图改变,抽血测定血脂、红细胞压积、血小板及内皮素水平的变化。结果:两组治疗后,患者心绞痛发作次数、持续时间以及硝酸甘油的用量明显减少,心电图明显改善,且LMWH组优于对照组(P<0.05)。LMWH治疗后,患者HCT、TC、TG及ET较治疗前明显降低(P<0.05)。对照组血浆ET水平无变化。结论:LMWH对UAP患者不仅具有抗凝抗栓作用,而且可以降低血液粘度、保护血管内皮细胞,纠正脂类代谢紊乱状态,
Objective: To observe the effect of low molecular weight heparin (LMWH) on clinical symptoms, electrocardiogram, blood lipid and endothelin (ET) in patients with unstable angina pectoris (UAP) .Methods: 84 UAP patients were prospectively divided into two groups: The control group received drugs such as nitroglycerin, metoprolol, aspirin, etc. The treatment group (LMWH group) was treated with LMWH (fast contraceptive) on the basis of the above treatment, before and after treatment to investigate the clinical symptoms and ECG changes, blood test for blood lipids, red blood cells The number of angina pectoris, the duration of angina pectoris and the amount of nitroglycerin were significantly decreased, the electrocardiogram was significantly improved, and LMWH group was better than the control group (P <0.05). After treatment with LMWH, the levels of HCT, TC, TG and ET in patients were significantly lower than those before treatment (P <0.05), while there was no change in the level of ET in the control group.Conclusion: LMWH not only has anticoagulant and antithrombotic effects but also can reduce the blood viscosity , Protect vascular endothelial cells, correct lipid metabolism disorders,