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目的探讨Fascin和C-erb B-2在膀胱尿路上皮癌表达的相关性及临床病理意义。方法运用免疫组化S-P法检测Fascin和C-erb B-2在10例膀胱癌旁粘膜及109例膀胱尿路上皮癌组织中的表达,分析表达水平与膀胱尿路上皮癌的组织学分级及临床分期等临床病理特征的关系,并分析Fascin和C-erb B-2在膀胱尿路上皮癌表达的相关性。结果 Fascin、C-erb B-2在10例癌旁粘膜组织中均不表达,在109例膀胱尿路上皮癌中的表达阳性率分别为83.5%、54.1%。Fascin和C-erb B-2的表达与膀胱尿路上皮癌的组织学分级、临床分期及淋巴结转移有关,与患者的性别及肿瘤是否多发无关。Fascin和C-erb B-2在膀胱尿路上皮癌的表达为正相关。结论推测在膀胱尿路上皮癌中Fascin和C-erb B-2具有协同作用,联合检测Fascin和C-erb B-2有助于判断膀胱尿路上皮癌的侵袭转移及预后。
Objective To investigate the correlation between the expression of Fascin and C-erb B-2 in bladder urothelial carcinoma and its clinicopathological significance. Methods The expression of Fascin and C-erb B-2 in 10 cases of paracancerous bladder mucosa and 109 cases of bladder urothelial carcinoma were detected by immunohistochemical SP method. The expression of Fascin and C-erb B- Clinical stage and other clinical and pathological features of the relationship between Fascin and C-erb B-2 in urothelial carcinoma of the urinary bladder cancer expression. Results The positive expression rates of Fascin and C-erb B-2 in 10 cases of paracancerous tissues were 83.5% and 54.1% respectively in 109 cases of bladder urothelial carcinoma. The expression of Fascin and C-erb B-2 was related to the histological grade, clinical stage and lymph node metastasis of bladder urothelial carcinoma, and had no relation with the sex and tumor occurrence. Fascin and C-erb B-2 expression in bladder urothelial carcinoma was positively correlated. Conclusions It is speculated that Fascin and C-erb B-2 have a synergistic effect in bladder urothelial carcinoma. Combined detection of Fascin and C-erb B-2 may be helpful to evaluate the invasion, metastasis and prognosis of bladder urothelial carcinoma.