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目的探讨血清细胞质胸苷激酶(TK1)检测在结直肠癌诊治中的临床价值。方法利用增强化学发光法(ECLA),检测150例结直肠癌患者血清、36例结直肠良性疾病患者血清和40例健康体检者血清中的TK1含量。结果结直肠癌患者血清TK1水平显著高于结直肠良性疾病组和正常对照组(P<0.01);而结直肠良性疾病组和正常对照组之间差异无统计学意义(P>0.05)。结直肠癌患者手术后血清TK1水平明显下降。结直肠癌患者血清TK1阳性率远远高于其他消化道肿瘤标志物[癌胚抗原(CEA)、糖抗原(CA199、CA724)]。结论血清TK1检测在结直肠癌的辅助诊断、监测疗效、判断预后等方面具有一定的临床应用价值。
Objective To investigate the clinical value of serum cytoplasmic thymidine kinase (TK1) in the diagnosis and treatment of colorectal cancer. Methods The levels of TK1 in sera of 150 patients with colorectal cancer, 36 patients with benign colorectal diseases and 40 healthy controls were detected by enhanced chemiluminescence (ECLA). Results The level of serum TK1 in patients with colorectal cancer was significantly higher than that in patients with benign colorectal diseases and normal controls (P <0.01). There was no significant difference between the benign disease group and normal controls (P> 0.05). The level of serum TK1 in colorectal cancer patients decreased significantly after operation. The positive rate of serum TK1 in patients with colorectal cancer is much higher than that of other gastrointestinal tumor markers (carcinoembryonic antigen (CEA), carbohydrate antigen (CA199, CA724)]. Conclusion The serum TK1 test has certain clinical value in the diagnosis, monitoring and prognosis of colorectal cancer.