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目的观察福辛普利对老年高血压心脏病患者的降压疗效及其对左室肥厚的逆转和舒张功能的改善作用。方法选择老年高血压伴左室肥厚患者33例,给予口服福辛普利10mg,每日1次,总疗程3个月。以彩色多普勒超声心动图观察治疗前、后心脏结构和舒张功能的改变情况。结果老年高血压心脏病患者治疗后收缩压、舒张压均有所下降。室间隔舒张末期厚度(IVSD)、左室后壁舒张末期厚度(LVPWD)较治疗前明显减轻。结论福辛普利能有效逆转高血压患者左心室肥厚,明显改善左心室舒张功能。
Objective To observe the antihypertensive effects of fosinopril on elderly patients with hypertensive heart disease and its effects on the reversal and diastolic function of left ventricular hypertrophy. Methods A total of 33 elderly hypertensive patients with left ventricular hypertrophy were enrolled in this study. Oral fosinopril 10 mg was given once daily for 3 months. Color Doppler echocardiography before and after treatment to observe changes in cardiac structure and diastolic function. Results After treatment, systolic blood pressure and diastolic blood pressure of elderly hypertensive heart patients decreased. Interventricular septum end-diastolic thickness (IVSD) and left ventricular posterior wall end-diastolic thickness (LVPWD) were significantly lower than those before treatment. Conclusion Fosinopril can effectively reverse the left ventricular hypertrophy in hypertensive patients and significantly improve the left ventricular diastolic function.