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细胞因子信号抑制蛋白1( SOCS1)是一种常见的抑制性信号调节蛋白,参与负反馈调节Janus激酶/信号转导及转录激活因子、Toll样受体信号通路、干扰素信号通路等,从而调控细胞因子、生长因子和激素对细胞的作用,这些信号通路在肿瘤的发生、发展中起一定的作用。其中以 SOCS-1基因启动子的甲基化所致的基因沉默最为热点,同时为卵巢恶性肿瘤机制的研究及治疗开辟了新的道路。“,”Suppressor of cytokine signaling 1 ( SOCS-1) is a common inhibitory signal regulating pro-tein,involved in the negative feedback regulation of Janus kinase/signal transductors and activatiors of tran-scription (JAK/STAT),TLR (Toll like receptor) signaling pathway,interferon signaling pathways,thereby regulating cytokines,growth factors and hormones on cell,playing a certain role in tumorigenesis and develop-ment.The gene silencing induced by the methylation of SOCS-1 gene promoter is the hottest focus in the field,which has opened up a new way for the study of mechanisms and treatment of malignant ovarian tumors.