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急性冠状动脉综合征（ ACS）是我国致死的首要病因之一，生化指标对有 ACS表现及征象患者的诊断、预后、指导治疗有重要作用。脑钠肽（BNP）及 N 端脑钠肽前体（NT－proBNP）是被公认的对心力衰竭（心衰）诊断和预后评估的生化指标。而近年来，随着研究进展，BNP及 NT－proBNP与ACS的关系备受关注。 BNP及NT－proBNP在ACS的诊断、预后评估及指导治疗中可能有重大意义。“,”Acute coronary syndrome(ACS)is one of the leading causes of death in China.Biomarkers have an essential role in diagnosis,prognosis,guiding the treatment in the setting of patients presenting with signs and symptoms of ACS.Brain natriuretic peptide(BNP) and N-terminal-proBNP(NT-proBNP) are rec-ognized as diagnosis and prognostic markers in patients with heart failure(HF).However recently,with the development of the research,increasing interests in the relation between BNP and NT-proBNP and ACS have been observed.BNP and NT-proBNP may have an important role in diagnosis, prognosis assessment and guiding the treatment of ACS,and here reviews the research progress of BNP,NT-proBNP and ACS.