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在一些国家麻疹是9月龄以下儿童死亡的主要原因。对这些国家建议使用高滴度Edmonston-Zagreb株麻疹疫苗(EZ-HT)对6月龄婴儿进行接种。然而,对于出生后较旱接种高滴度麻疹疫苗的远期影响了解甚少。在塞内加尔农村对1015名新生儿随机分组,336名儿童在5月龄接种EZ-HT;321名5月龄儿童接种Schwarz株(SW-HT)疫苗,358名5月龄儿童接种安慰剂。随后在10月龄时接种常规的低滴度Schwardz疫苗,388名未接种疫苗者为对照。对所有受试者随访24～39个月。这三组儿童的社会、家庭和健康状况相似,也不存在其他附加条件。
In some countries, measles is the leading cause of death among children under 9 months of age. It is recommended for these countries to vaccinate 6-month-old infants with high-titer Edmonston-Zagreb measles vaccine (EZ-HT). However, little is known about the long-term impact of a higher-dose measles vaccine on droughts after birth. 1,015 newborns were randomly grouped in rural Senegal; 336 children were immunized with EZ-HT at 5 months of age; 321 five-month-old children vaccinated with Schwarz strain (SW-HT) and 358 five-month-old children were vaccinated with placebo. The conventional low titer Schwardz vaccine was then vaccinated at 10 months of age and 388 unvaccinated controls served as controls. All subjects were followed up for 24 to 39 months. The three groups of children have similar social, family and health status, and no other additional conditions exist.