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美国一般采用两类乙型肝炎疫苗:血源疫苗和酵母重组疫苗。不过,血源疫苗已不再生产,使用也限于血液透析病人、免疫损害者和对酵母过敏者。在3剂乙型肝炎疫苗的免疫程序中,血源疫苗和重组疫苗交替使用早有评价。但是,两种不同的重组疫苗是否可交替使用,这个经常由卫生保健工作者提出的问题尚未作过研究,本文作者就一种重组疫苗接种后,再用另一种重组疫苗完成全程免疫的效果进行了评价。48名健康医务工作者(女42,男6,年龄23～48岁),接种前乙型肝炎血清学标志均为阴性,按0、1、6月程序免疫。0及1月各接种Merck药厂的重组疫苗(MSD rDNA)10μg。首针后6个月,全部对象采血一次,然后以计算机随机分成两组,两组的性别、种族、年龄、体重和人数均相似。按双盲法接种Smith
The United States generally uses two types of hepatitis B vaccines: blood-borne vaccines and yeast recombinant vaccines. However, blood-borne vaccines are no longer manufactured and use is limited to hemodialysis patients, immunocompromised patients and those who are allergic to yeast. In the three-dose hepatitis B vaccine immunization program, blood-borne and recombinant vaccines were used interchangeably. However, whether the two different recombinant vaccines can be used interchangeably, a question often raised by health care workers has not been studied. The author of this article retested the immunization with another recombinant vaccine after a recombinant vaccination did an evaluation. Forty-eight healthy medical workers (42 females, 6 males and 23 to 48 years old) were immunized with 0, 1, and 6-month serological markers before vaccination. 0 and January were vaccinated Merck pharmaceutical recombinant vaccine (MSD rDNA) 10μg. Six months after the first call, all subjects were bled once and then randomly divided into two groups by computer. The two groups were similar in terms of sex, race, age, weight and number of people. Smith was vaccinated double-blindly