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[目的]观察清肺止咳平喘颗粒的止咳、化痰、平喘作用。[方法]采用小鼠氨水诱咳法观察镇咳作用;采用小鼠酚红排泌法观察化痰作用;采用豚鼠卵蛋白喷雾引喘法观察平喘作用;采用小鼠二甲苯致炎观察抗炎作用。[结果]清肺止咳平喘颗粒能显著减少浓氨水引起小鼠咳嗽次数并延长咳嗽潜伏期,能增加小鼠呼吸道的酚红排泌量,能延长豚鼠哮喘潜伏期,并能显著降低豚鼠BALF中白细胞数量。[结论]清肺止咳平喘颗粒具有明显止咳、化痰、平喘作用。
[Objective] To observe the effect of Qingfei Zhike Pingchuan Granule on cough, phlegm and asthma. [Methods] Antitussive effect was observed by mouse ammonia cough induction method; phlegm-removing effect was observed by phenol red excretion; guinea pig egg protein spray induced asthma was used to observe antiasthmatic effects; Inflammation. [Results] Qingfei Zhike Pingchuan Granules can significantly reduce the number of coughing and prolong the cough latency of mice caused by concentrated ammonia, increase the phenol red excretion in respiratory tract of mice, prolong the latency of asthma in guinea pigs, and significantly reduce white blood cells in guinea pig BALF. Quantity. [Conclusion] Qingfei Zhike Pingchuan Granules has obvious antitussive, expectorant and antiasthmatic effects.