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目的：探讨血管内皮生长因子与膀胱癌浸润及复发的关系。方法：应用ＬＳＡＢ免疫组织化学技术检测４０例膀胱移行细胞癌血管内皮生长因子（ＶＥＧＦ）的表达。结果：膀胱癌细胞ＶＥＧＦ的表达率为５５％（２２／４０），浸润性癌组ＶＥＧＦ的表达显著高于表浅性癌组（Ｐ＜０．０１），有淋巴结转移癌组显著高于无转移癌组（Ｐ＜０．０５），复发性癌组较初发性癌组差异有显著性（Ｐ＜０．０１）。结论：ＶＥＧＦ可作为判断膀胱癌生物学行为的指标之一。
Objective: To investigate the relationship between vascular endothelial growth factor and invasion and recurrence of bladder cancer. Methods: The expression of vascular endothelial growth factor (VEGF) in 40 cases of bladder transitional cell carcinoma was detected by LSAB immunohistochemistry. RESULTS: The expression rate of VEGF in bladder cancer cells was 55% (22/40). The expression of VEGF in invasive cancer was significantly higher than that in the superficial cancer group (P<0.01). The patients with lymph node metastasis were significantly higher than those without cancer. In the metastatic cancer group (P<0.05), there was a significant difference between the recurrent cancer group and the primary cancer group (P<0.01). Conclusion: VEGF can be used as one of the indicators to judge the biological behavior of bladder cancer.