论文部分内容阅读
用低碘饲料复制了连续多代的大鼠克汀病模型，研究了第1代和第2代子鼠的学习记忆能力和重建的海马三维结构。结果表明．与正常组大鼠比较，克汀病于鼠生长发育迟缓，甲状腺呈增生性甲状腺肿病变，其血清甲状腺激素水平降低，逃避防御条件反射显示学习记忆能力低下等。以上病变在第二代克汀鼠明显重于第一代。海马结构损害是克河病大鼠学习记忆能力低下的形态学基础。
The hypoglycemic diet was used to replicate the murine model of cretinism for generations. The learning and memory abilities of the first and second generation offspring and the reconstructed hippocampal three-dimensional structure were studied. The results show. Compared with normal rats, cretinism slow growth in rats, thyroid was hyperplastic goiter lesions, serum thyroid hormone levels decreased, escaping defensive reflex showed low learning and memory and so on. More lesions in the second generation Kettin mice significantly heavier than the first generation. Damage of hippocampal formation is the morphological basis of learning and memory deficits in gram-deficient rats.