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过氧化物酶体增殖剂激活受体(peroxisome proliferator-activated receptors,PPARs)是配体依赖型核受体,目前发现PPARs具有多种亚型,包括有PPAR-α、PPAR-β和PPAR-γ等,其中对PPAR-γ的研究最为深入。PPAR-γ在细胞信号转导中起重要作用,参与调节细胞内许多功能,如脂肪细胞分化、脂质代谢、免疫细胞活化和炎症介质生成等。近年来的一些研究也显示,PPAR-γ在卵巢组织周期性调控中也发挥着重要的作用,如促进排卵等。在卵巢组织中,PPAR-γ可由卵巢组织自身产生,并参与调控卵巢的周期性变化;同时,脂肪或巨噬细胞中激活的PPAR-γ可能通过脂质代谢或炎症介导因子而对卵巢产生重要影响。
Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent nuclear receptors, PPARs have been found in many subtypes, including PPAR-α, PPAR-β and PPAR-γ Among them, the research on PPAR-γ is the most in-depth. PPAR-γ plays an important role in cell signal transduction and is involved in the regulation of many intracellular functions such as adipocyte differentiation, lipid metabolism, immune cell activation and inflammatory mediator production. In recent years, some studies have also shown that PPAR-γ also plays an important role in the periodic regulation of ovarian tissue, such as promoting ovulation. In ovarian tissue, PPAR-γ is produced by ovarian tissue itself and is involved in the regulation of ovarian cyclical changes. At the same time, activated PPAR-γ in fat or macrophages may produce ovarian by lipid metabolism or inflammation mediating factor Significant influence.