Synthesis of fused pyran and arylbis(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methane in ionic liquid

• 出 处: Chinese Chemical Letters
• 发表日期: 2009年04期
• 关键词: pyran fused pyrimidine ionic anhydride methane aldehyde nucleoside acetic reused

Promoted and mediated by an ionic liquid-[bmim][BF_4],fused pyrans or arylbis(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl) methanes were efficiently and selectively prepared from the reaction of aldehyde and 4-hydroxy-6-methyl-2-oxo-pyran with or without acetic anhydride.By using these novel procedures,pyrimidine nucleoside-fused pyran and arylbis(pyranon-3-yl)methane hybrids with potential biological activities were constructed.

Promoted and mediated by an ionic liquid- [bmim] [BF_4], fused pyrans or arylbis (4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl) methanes were efficiently and selectively prepared from the reaction of aldehyde and 4-hydroxy-6-methyl-2-oxo-pyran with or without acetic anhydride. or by using these novel procedures, pyrimidine nucleoside-fused pyran and arylbis (pyranon- 3-yl) methane hybrids with potential biological activities were constructed.