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本实验通过比较组胺引起的肺与呼吸系统顺应性、导纳的改变，以验证组胺引起的肺反应可由呼吸系统反应正确评估．结果表明，静脉滴注组胺可引起肺顺应性（ＣＬ），呼吸系统顺应性（Ｃｒｓ），肺导纳（ＧＬ），呼吸系统导纳（Ｇｒｓ），Ｐａｏ２及ｐＨ显著降低（Ｐ＜０．０５），Ｐａｃｏ２及Ｑｓ／Ｑｔ显著升高（Ｐ＜０．０５）．在组胺滴注时，ＣＬ与Ｃｒｓ（ｒ＝０．９５，Ｐ＜０，０１），ＧＬ与Ｇｒｓ（ｒ＝０．９５，Ｐ＜０．０１）均呈显著正相关．结果提示，呼吸系统反应为评价组胺致肺损伤犬的肺反应提供了一种简便、精确的方法．
This experiment by comparing histamine caused lung and respiratory compliance, admittance changes in order to verify histamine-induced lung response can be correctly assessed by the respiratory reaction. The results showed that intravenous instillation of histamine resulted in a significant decrease of lung compliance (CL), respiratory compliance (Crs), pulmonary admittance (GL), respiratory admittance (Grs), Pao2 and pH (P <0. 05), Paco2 and Qs / Qt were significantly increased (P <0.05). There was a significant positive correlation between CL and Crs (r = 0.95, P <0.01), GL and Grs (r = 0.95, P <0.01) during histamine instillation. The results suggest that the respiratory response provides a simple and accurate method for evaluating lung response in histamine-induced lung injury in dogs.