Emerging roles for insulin-like growth factor binding protein like protein 1

• 作 者: Yingqian Li Eric Zhao Dong Feng Chen
• 机 构: Schepens Eye Research Institute of Massachusetts Eye and Ear,Department of Ophthalmology, Harvard Me
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2019年2期

Insulin-like growth factors (IGFs) mediate diverse cellular processes in various tissues,including the central nervous system (CNS) and thus require robust and delicate regulatory mechanisms.It is now known that IGF signaling is regulated by a superfamily of IGF binding proteins (IGFBPs) which share significant sequence homology and are secreted to the extracellular environment to bind IGF (Nguyen et al.,2013).Currently,there are 6 known IGFBPs and 10 IGFBP related proteins.A new member of the IGFBP superfamily,IGFBP like protein 1 (IGFBPL1),was then identified and shown to have tumor suppressor like properties (Smith et al.,2007).Since then,little has been reported about the physiological roles of IGFBPL1.Recently,IGFBPL1 was found to be critically involved in mediating IGF-1 signaling to control CNS axon growth and regeneration (Guo et al.,2018).The study has uncovered a new signaling loop in the regulation of the pleiotropic functions of IGF1 and presents a possible novel pharmacological manipulation for promoting nerve regeneration and repair.