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肿瘤坏死因子α诱导蛋白8-2(turmor necrosis factor-α-induced protein-8-like2,TNFAIP8L2,TIPE2)是近年来发现的免疫负调控分子,其通过对TCR和TLR进行信号转导,调控固有免疫应答和适应性免疫应答,维持机体免疫稳态。本文总结了TIPE2的组织学分布及其与免疫和炎症性疾病之间的关系。
Turmor necrosis factor-α-induced protein-8-like2 (TNFAIP8L2, TIPE2) is a negative immunoregulatory molecule found in recent years. It regulates intrinsic TCR and TLR by signal transduction. Immune response and adaptive immune response, maintain the body immune homeostasis. This article summarizes the histological distribution of TIPE2 and its relationship to immune and inflammatory diseases.