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五十年代有人报道服用安眠药 Thalidomide 后有致畸胎副作用事例,以后人们更重视药物的致畸胎副作用。迄今,已知有致畸胎副作用的药物为同位素碘(~(131)I)和 Thalidomide 等。但判别某一种药物是否有致畸胎副作用,至今尚有困难。因为一方面对胎儿生长发育的各种生理结构还不充分明瞭;另一方面,影响胎儿死亡或先天异常的因素很多,难以判别究竟是药物所致的畸胎还是母体对胎儿的影响,抑或是胎儿在生长发育过程中因其他原因所造成的。众所周知,在人群中普查,也有一定数量的畸形婴儿出生。日本森山(1966)报道1957～1961年334,529名出生中,畸胎2,209名,占0.66%。因此,要了解某种药物所致胎儿畸
In the 1950s, it was reported that there were cases of teratogenic side effects after taking sleeping pills Thalidomide, after which people pay more attention to the teratogenic side effects of the medicines. Hitherto, the drugs known to have side effects of teratogenicity are isotope iodine (~ (131) I) and Thalidomide et al. However, it is still difficult to determine if a certain kind of medicine has teratogenic side effects. Because on the one hand, the growth and development of the fetus on the one hand, a variety of physiological structures are not fully understood; the other hand, there are many factors that affect the fetal death or congenital anomalies, it is difficult to tell whether the drug-induced teratogenic or maternal impact on the fetus, or Fetus in the process of growth and development for other reasons. As we all know, in the census of the population, there are also a certain number of deformed babies born. Moriyama (1966) reported that 2,209 teratosomes accounted for 0.66% of 334,529 births from 1957 to 1961. Therefore, to understand the fetal malformations caused by a drug