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目的:研究肠内营养在直肠癌术后急性放射性肠炎中的临床应用。方法:选择2012年7月~2013年7月在我院接受治疗的104例直肠癌手术后发生急性放射性肠炎的患者作为研究对象。依照数字法随机分成观察组(51例)和对照组(53例)。对照组予以(半)流质食物,观察组则予以能全力肠内营养支持治疗。分别在治疗前以及治疗后7d测定血生化、营养以及电解质指标。结果:经7d治疗后,观察组的前白蛋白(PA)、白蛋白(Alb)、视黄醇结合蛋白(RBP)及体重(BW)水平均显著高于治疗前以及对照组,C反应蛋白(CRP)显著低于对照组,差异均有统计学意义(均P<0.05);但两组治疗后的总蛋白(TP)水平差异无统计学意义(P>0.05);两组治疗前后的谷丙转氨酶(ALT)、血清碱性磷酸酶(AKP)、凝血酶原时间(PT)、胆红素(BIL)、尿素氮(BUN)、肌酐(Cr)及血糖(Glu)等血生化指标以及钾离子(K+)、钠离子(Na+)、氯离子(Cl-)、钙离子(Ca2+)等电解质指标的差异均无统计学意义(均P>0.05)。结论:通过肠内营养治疗直肠癌手术后发生的放射性肠炎,可改善患者的营养状况,效果显著,值得推广。
Objective: To study the clinical application of enteral nutrition in the treatment of acute radiation enteritis after rectal cancer. Methods: A total of 104 patients with acute radiation enteritis after rectal cancer surgery in our hospital from July 2012 to July 2013 were selected as the research object. According to the digital method, they were randomly divided into observation group (51 cases) and control group (53 cases). The control group was given (semi) liquid food, the observation group was given full enteral nutrition support treatment. Blood biochemistry, nutrition and electrolytes were measured before treatment and 7 days after treatment respectively. Results: After 7 days of treatment, the levels of albumin (PA), albumin (Alb), retinol binding protein (RBP) and body weight (BW) in the observation group were significantly higher than those before treatment and in the control group (P <0.05). However, there was no significant difference in the total protein (TP) levels between the two groups after treatment (P> 0.05). The levels of CRP in the two groups before and after treatment were significantly lower than those in the control group ALT, AKP, PT, BIL, BUN, creatinine and Glu were determined by real-time quantitative real-time PCR (K +), sodium (Na +), chloride (Cl-), calcium (Ca2 +) and other electrolytes were not significantly different (all P> 0.05). Conclusions: Radiation enteritis, which occurs after enteral nutrition treatment of rectal cancer surgery, can improve the nutritional status of patients with significant effects and is worth promoting.