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本文报道了用小量阿斯匹林(Acetylsalicylic Acid ASA)防治老年人缺血性脑血管病108例,按每日100毫克、50毫克、25毫克分三组每组各36例。各组皆取得了满意的治疗效果,而以50毫克组效果最佳。动态观察了64例血小板聚集力的变化。对其中22名正常人监测结果提示一次用药300毫克或100毫克对血小板聚集力的抑制作用可达7天之久,提示临床可应用比100毫克更小的剂量。另外对上述三组各14例的监测结果提示服药后血小板聚集力同样获得了满意的抑制效果,而抑制程度以50毫克组为佳。故我们提出小量ASA防治老年人缺血性脑血管病的适宜剂量为每日50毫克。
This article reports the use of a small amount of aspirin (Acetylsalicylic Acid ASA) prevention and treatment of elderly ischemic cerebrovascular disease in 108 cases, 100 mg daily, 50 mg, 25 mg divided into three groups of 36 cases each. All groups have achieved satisfactory therapeutic effect, while the effect of 50 mg group best. Dynamic observation of 64 cases of platelet aggregation changes. Monitoring results of 22 of them showed that the inhibition of 300 mg or 100 mg on platelet aggregation could reach 7 days, suggesting that a dose smaller than 100 mg could be applied clinically. In addition to the above three groups of 14 cases of monitoring results suggest that the platelet aggregation after taking the same satisfactory inhibitory effect, and the degree of inhibition in the group of 50 mg better. Therefore, we propose a small dose of ASA for the prevention and treatment of ischemic cerebrovascular disease in adults the appropriate dose of 50 mg per day.