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氟康唑是一类新的双三唑抗真菌药,与同类药物相比,具有良好的药物动力学特性及较低的毒性等优点。作用机理:主要是抑制生物体内麦角甾醇的生物合成。动物体内抗真菌活性试验表明:氟康唑在体内分布广泛,对多种系统真菌感染有效,易于渗入脑脊液。本文就其临床应用作一概述。1 口咽部、食管和口腔念珠菌病 在一次随机双盲研究中,De Wits等对口服50mg/d氟康唑和200mg/d酮康唑治疗艾滋病和艾滋病相关综合征病人的口咽部念珠菌病的效果和耐受性进行了比较,结果用氟康唑治疗的所有感染发作均达到临床治愈。用酮康唑治疗的16次发作中12
Fluconazole is a new class of bis-triazole antifungal agents that have good pharmacokinetic properties and lower toxicity compared to similar drugs. Mechanism of action: mainly inhibit the bio-body ergosterol biosynthesis. Anti-fungal activity in animals tests showed that: Fluconazole in the body widely distributed on a variety of systemic fungal infections, easy to infiltrate cerebrospinal fluid. This article gives an overview of its clinical application. Oropharyngeal, esophageal and oral candidiasis In a randomized, double-blind study, De Wits et al treated oral oropharyngeal rosaries of patients with AIDS and AIDS-related syndromes with oral administration of 50 mg / day fluconazole and 200 mg / day ketoconazole The efficacy and tolerability of the mycosis were compared, with the result that all infections treated with fluconazole achieved clinical cure. In 16 episodes of treatment with ketoconazole 12