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了解促黄体生成激素释放激素激动剂（丙氨瑞林）对人卵巢上皮性癌HO－8910细胞的作用。方法：用MTT比色法和计细胞分裂指数方法，检测与不同浓度丙氨瑞林（0．1－1000nmol／L）共同培养48小时后的人卵巢上皮性癌HO－8910细胞。结果：丙氨瑞林可抑制癌细胞的增殖，使核分裂指数明显降低，与对照比较P＜0．01，MTT比色结果显示抑制作用存在着量效关系，10nmol／L浓度的丙氨瑞林可明显抑制HO－8910细胞的增殖，与对照比较差异有显著性意义（P＜0．05）。结论：丙氨瑞林在体外可明显抑制HO－8910细胞的增殖。
To investigate the effect of luteinizing hormone-releasing hormone agonist (ararelin) on human ovarian epithelial carcinoma HO-8910 cells. Methods: Human ovarian epithelial carcinoma HO-8910 cells were cultured with different concentration of avermectin (0.1-1000 nmol / L) for 48 hours by MTT assay and cell division index method. RESULTS: Alarelin could inhibit the proliferation of cancer cells and reduce the mitotic index. Compared with the control, P <0.01, the MTT results showed that there was a dose-response relationship between the inhibition and the effect of 10 mmol / L ararelin The proliferation of HO-8910 cells was significantly inhibited, which was significantly different from the control (P <0.05). CONCLUSION: Alarelin significantly inhibits the proliferation of HO-8910 cells in vitro.