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[目的]研究甲基强的松在急性播散性脑脊髓炎患儿治疗中对免疫功能状态的影响。[方法]将2008年8月~2010年8月我科就诊的30例急性播散性脑脊髓炎设为观察组,以30例健康体检儿作为对照组,在抗病毒及对症治疗的基础上,加用甲基强的松治疗。采用免疫比浊法检测两组血免疫球蛋白IgA、IgE、IgG和IgM。[结果]治疗前观察组的IgG、IgM显著高于对照组(P﹤0.01),而IgA、IgE变化差异无统计学意义(P﹥0.05)。治疗后,观察组的IgG和IgM均显著低于治疗前(P﹤0.01),而IgA、IgE差异无统计学意义(P﹥0.05)。[结论]甲基强的松有助于改善患儿的免疫状态,减慢急性脱髓鞘病变组织的炎症和水肿,利于降低病死率及致残率,减少后遗症的发生率及后遗症的严重程度。
[Objective] To study the effect of methylprednisolone on immune function in children with acute disseminated encephalomyelitis. [Methods] Thirty patients with acute disseminated encephalomyelitis treated in our department from August 2008 to August 2010 were selected as observation group and 30 healthy children as control group. On the basis of anti-virus and symptomatic treatment , Plus methyl prednisone treatment. Two groups of immunoglobulin IgA, IgE, IgG and IgM were detected by immunoturbidimetry. [Results] The levels of IgG and IgM in the observation group before treatment were significantly higher than those in the control group (P <0.01), while the changes of IgA and IgE in the observation group were not statistically significant (P> 0.05). After treatment, the levels of IgG and IgM in the observation group were significantly lower than those before treatment (P <0.01), while there were no significant differences in IgA and IgE (P> 0.05). [Conclusion] Methylprednisone can improve the immune status of children, reduce the inflammation and edema in acute demyelinating lesions, reduce the mortality and morbidity, reduce the incidence of sequelae and the severity of sequelae .