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用放射免疫法测定了121例肝硬变患者和50例年龄、性别相称的对照者血浆内皮素水平,并探讨了与合并腹水者内毒素血症的关系。结果表明,肝硬变患者血浆内皮素水平比对照组明显增高(股动脉:82.51±19.71pg/ml,30.09±7.99pg/ml,P=0.000;股静脉:90.29±23.07pg/ml,34.01±7.59pg/ml,P=0.000;贵要静脉:87.41±22.99pg/ml,32.69±8.16pg/ml,P=0.000)。此外,合并腹水的肝硬变患者静脉血内皮素含量比无腹水患者增高明显(106.41+17.13pgmml,90.29±23.07pg/ml,P=0.002)股静脉血浆内皮素含量与内毒素血症的严重程度呈正相关(r_s=0.61,P=0.034)。
The plasma endothelin levels in 121 cirrhotic patients and 50 age-matched and gender-matched controls were determined by radioimmunoassay and the relationship with endotoxemia in patients with cirrhosis. The results showed that the plasma endothelin levels in patients with cirrhosis were significantly higher than those in the control group (femoral artery: 82.51 ± 19.71pg / ml, 30.09 ± 7.99pg / ml, P = 0.000; femoral vein: 90.29 ± 23.07pg / ml, 34.01 ± 7.59 pg / ml, P = 0.000; dwelling venous: 87.41 ± 22.99 pg / ml, 32.69 ± 8.16 pg / ml, P = 0.000). In addition, venous blood endothelin levels in cirrhotic patients with ascites were significantly higher than those without ascites (106.41 + 17.13 pgmml, 90.29 ± 23.07 pg / ml, P = 0.002). Serum endothelin levels and endotoxemia The degree was positively correlated (r_s = 0.61, P = 0.034).