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目的：观察凝血酶对应激性溃疡出血的局部止血作用。方法：应激性溃疡并出血病人４５ 例，男性２８ 例，女性１７ 例，年龄３６ ａ ±ｓ １４ ａ 。将凝血酶２０００ ～４０００ Ｉ Ｕ 用０ ．９ ％ 氯化钠注射液溶解配成５０ Ｉ Ｕ／ｍ Ｌ， 自留置的胃管注入（ 每次注入４０ ～８０ｍ Ｌ） ，转动病人体位，使药液与出血创面充分接触。ｑ １ ～２ ｈ 给药１ 次，待呕血和黑便停止后改为６ ｈ １次。最少用药２ 次，最多用药４ ｄ 。结果：显效３２ 例（７１ ％ ） ，有效９ 例（２０ ％ ） ，无效４ 例（９ ％ ） ，总有效率９１ ％ ，无不良反应。结论：凝血酶局部用药治疗应激性溃疡出血疗效好。
Objective: To observe the local hemostatic effect of thrombin on the bleeding of stress ulcer. Methods: Forty-five patients with stress ulcer and bleeding, 28 males and 17 females, aged 36 ± 14 years. Thrombin 2000 ~ 4000 I U with 0. 9% sodium chloride solution dissolved into 50 IU / m L, from the gastric tube into the injection (each injection of 40 ~ 80m L), rotating the patient position, so that the liquid and the bleeding wounds fully exposed. q 1 ~ 2 h administration 1, to be hematemesis and black stool changed to 6 h 1 times. At least medication 2 times, up to medication 4 d. Results: 32 cases (71%) were markedly effective, 9 cases (20%) effective, 4 cases (9%) ineffective and the total effective rate was 91%. No adverse reactions were observed. Conclusion: Topical thrombin treatment of stress ulcer bleeding effect.