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观察在双支经皮冠状动脉腔内成形术（PTCA）中缺血预处理对非同一缺血部位心肌的作用。14例患者均为两支冠状动脉（冠脉）病变。分别观察两支冠脉成形时心绞痛程度、狭窄冠脉相关导联心电图最大ST段抬高幅度和发生时间双冠状窦静脉血浆和血清中血栓素B2（TXB2）和6-酮─前列腺素F1α（6－keto－PGF1α）浓度。观察到两支冠脉狭窄程度及PTCA参数无明显差别，但第二支冠脉PTCA时心绞痛积分及发生时间和心电图最大ST段抬高幅度及发生时间均显著低于或迟于第一支冠脉PTCA时（P＜0.05）。第二文冠脉PTCA前后血浆6－keto－PGF1α水平均高于第一支（P＜0．05）。提示缺血预处理可以保护非同一缺血部位的心肌，其机制可能同前列环素的改变有关。
To observe the effect of ischemic preconditioning on myocardium in the same ischemic area in double-vessel percutaneous transluminal coronary angioplasty (PTCA). All 14 patients had two coronary artery lesions. The extent of angina pectoris during coronary angioplasty, the maximum ST segment elevation at electrocardiogram of stenosis-associated coronary artery, and the time of occurrence of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α 6-keto-PGF1α) concentrations. No significant difference was observed in the degree of coronary stenosis and PTCA between the two coronary arteries. However, the integral and time of angina pectoris and the maximum ST segment elevation and time of electrocardiogram in the second coronary artery were significantly lower or later than those in the first coronary artery Pulse PTCA (P <0.05). The plasma 6-keto-PGF1α level in the second coronary artery before and after PTCA was higher than that in the first branch (P <0.05). It is suggested that ischemic preconditioning can protect the myocardium of the same ischemic site, the mechanism may be related to the change of prostacyclin.