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为研究细菌性脑膜炎儿童抗炎物质(IL-10、sTNFR-55和sTNFR-75)的作用和其与炎性介导细胞因子(TNF-α、IL-6、IL-8)之间的关系,作者对37例患儿血清和CSF中的这些介质作了检测,并研究了这些介质在CSF腔隙的动力学和其与CSF特征之间的关系。 患儿年龄3个月～18岁,平均3.3岁。其中男17例,女20例,排除预先用抗生素治疗的病人。收集大多数病人初期的CSF和血清标本。部分病人在抗生素治疗后的6、12、24小时随机进行两次腰穿。血清和CSF配对对照标本取自儿科处于缓解期的癌症病
To investigate the role of anti-inflammatory substances (IL-10, sTNFR-55 and sTNFR-75) in children with bacterial meningitis and their relationship with inflammatory mediators of cytokines (TNF-α, IL-6 and IL-8) The authors tested these media in 37 children with serum and CSF and studied the kinetics of these mediators in the CSF lacuna and their relationship to CSF characteristics. Children aged 3 months to 18 years old, with an average of 3.3 years old. There were 17 males and 20 females, with the exception of patients treated with antibiotics in advance. Collected initial CSF and serum samples from most patients. Some patients were randomized to lumbar puncture 6,12,24 hours after antibiotic treatment. Serum and CSF paired control samples were taken from pediatric patients with remission cancer