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哮喘的发病机理目前尚不清楚,近年认为是气道变应性炎症和气道高反应所致。目前治疗原则为类固醇类抗炎症、支气管解痉及抗感染治疗。本文用IVIG治疗25例小儿支气管哮喘,观察其临床疗效和对血清IgE及单个核细胞(PBMC)体外产生IL-4、IFN-γ的影响,以探讨IVIG治疗哮喘的效果及可能的作用机理。 资料与结果 一、对象 收集50例住院急性发作期哮喘患儿,均符合全国儿科呼吸协作组1993年小儿哮喘诊断标准.随机分为两组,IVIG组25例,男18例,女7例,年龄10月～11岁;对照组25例,男17例,女8例,年龄1～10岁。两组患儿病情轻重无明显差异,均在用药前和用药后3～6天采血,即刻分离PBMC培养。血清—20℃冻存待检。
The pathogenesis of asthma is not yet clear in recent years that airway allergic inflammation and airway hyperresponsiveness caused. The current treatment principles for steroid anti-inflammatory, bronchial spasm and anti-infection treatment. In this paper, 25 children with bronchial asthma were treated with IVIG. The clinical efficacy and the effects of IL-4 and IFN-γ on serum IgE and mononuclear cells (PBMCs) in vitro were observed to explore the effect of IVIG on asthma and its possible mechanism. MATERIALS AND RESULTS 1. Subjects All 50 children with acute asthma exacerbated during hospitalization were enrolled in the Pediatric Asthma Pediatric Breathing Cooperative Group, which were diagnosed by pediatric asthma in 1993. They were randomly divided into two groups: 25 cases in IVIG group, 18 males and 7 females, The age ranged from 10 months to 11 years. The control group included 25 cases, 17 males and 8 females, aged from 1 to 10 years old. Two groups of children with no significant difference in severity, both before treatment and after 3 to 6 days blood collection, PBMC culture immediately separated. Serum -20 ℃ frozen pending.