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背景:1950年至1980年间荷兰结核病感染率的下降比发病率的下降快得多。本研究的目的在于确定这一现象是否能用年龄组内的不同传播所解释。方法:应用RFLP法将荷兰1993～1996年所有菌株进行分型,同一指印的菌株被鉴定为同一来源,由此确定2个荷兰患者年龄上的相关性。结果:两簇人群81对菌株患者年龄的平均差异是13.9岁。而所有可能配对患者资料的年龄平均差异是25.5岁。Fisher氏检验相关系数为0.62 (95%可信区间[CI]值为0.46～0.74)。结论:结核病传染源更易传染给和他们年龄相近的人群。由于在1950～1980年间,病例的平均年龄在增加。传染源可能对过去常观测年感染率的儿童的感染更少。在低结核国家中儿童、青少年结核病的年感染率的资料不适于该人群中的老年者。
Background: The decline in tuberculosis infection in the Netherlands between 1950 and 1980 was much faster than the decline in incidence. The purpose of this study is to determine whether this phenomenon can be explained by the different transmission within the age group. Methods: All the strains in the Netherlands from 1993 to 1996 were genotyped by RFLP, and the same fingerprinted strains were identified as the same source, thus determining the age-related associations between the two Dutch patients. Results: The average age difference of 81 strains in two cluster populations was 13.9 years. The average age difference for all paired patient data is 25.5 years. Fisher’s test showed a correlation coefficient of 0.62 (95% confidence interval [CI], 0.46 to 0.74). Conclusion: Sources of TB infection are more likely to be transmitted to people of similar age. As the average age of cases increased between 1950 and 1980. Sources of infection may be less infectious to children who used to observe annual infection rates. Information on the annual prevalence of tuberculosis in children and adolescents in low-TB countries is not appropriate for the elderly in this population.