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目的探讨小剂量雌激素对绝经后妇女泌尿系统反复感染的预防和治疗作用。方法选择2011年1月至2013年7月被诊断为泌尿系统反复感染的绝经后妇女74例,随机分为观察组与对照组两组各37例,观察组与对照组同时给予左氧氟沙星治疗,观察组在此基础上加用小剂量雌三醇软膏,遵医嘱连续治疗1个疗程(3个月),记录并比较治疗前后两组阴道健康评分及复发性尿道炎症评分。结果观察组和对照组治疗后总有效率分别为94.6%和73.0%。雌三醇(E3)停药3个月和6个月后,观察组复发率明显低于对照组,两组差异有统计学意义(P<0.05);停药9个月后,观察组复发率升高(24.3%),与对照组(29.7%)比较差异未见统计学意义(P>0.05)。结论小剂量雌激素预防治疗绝经后妇女泌尿系统反复感染,能显著提高临床治愈率,明显降低复发率,为临床的应用推广提供了理论依据。
Objective To investigate the preventive and therapeutic effects of low dose estrogen on recurrent urinary tract infections in postmenopausal women. Methods Seventy-four postmenopausal women diagnosed as recurrent urinary tract infection from January 2011 to July 2013 were randomly divided into observation group and control group, 37 cases in each group. The observation group and the control group were treated with levofloxacin, On this basis, a small dose of estriol ointment was added to the group. One course of treatment (3 months) was prescribed as prescribed by the doctor. Vaginal health score and recurrent urethritis score were recorded and compared before and after treatment. Results The total effective rates of the observation group and the control group after treatment were 94.6% and 73.0% respectively. Estriol (E3) withdrawal 3 months and 6 months after the observation group recurrence rate was significantly lower than the control group, the difference between the two groups was statistically significant (P <0.05); withdrawal after 9 months, the observation group relapse (24.3%), but no significant difference compared with control group (29.7%) (P> 0.05). Conclusion Low-dose estrogen can prevent urinary tract infection in postmenopausal women, which can significantly improve the clinical cure rate and significantly reduce the recurrence rate, providing a theoretical basis for clinical application and promotion.