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目的：建立大鼠局灶性脑缺血模型，测定大鼠局灶性脑缺血血脑屏障破坏的程度，并观察黄芪甲苷对局灶性脑缺血后血脑屏障破坏的影响。方法：采用大脑中动脉插线法建立大鼠局灶性脑缺血模型，并采用Ｅｖａｎｓ蓝静脉注射观察其血脑屏障破坏的程度。结果：注射黄芪甲苷组血脑屏障的通透性比单纯的缺血组明显降低。结论：黄芪甲苷是一种脑组织保护剂，可以降低血脑屏障的通透性，保护脑组织。
OBJECTIVE: To establish a rat model of focal cerebral ischemia, to determine the degree of destruction of blood-brain barrier in rats with focal cerebral ischemia, and to observe the effect of astragaloside IV on the destruction of blood-brain barrier after focal cerebral ischemia. METHODS: A rat model of focal cerebral ischemia was established using the middle cerebral artery interventional method. Evans blue vein injection was used to observe the degree of damage of the blood-brain barrier. Results: The permeability of the blood-brain barrier after injection of astragaloside was significantly lower than that of the ischemic group alone. CONCLUSION: Astragaloside is a brain tissue protectant that can reduce the permeability of the blood-brain barrier and protect brain tissue.