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结构稍加修饰的天然核苷类似物在病毒复制过程中是以某些关键酶为专属靶点的.这些修饰包括在嘧啶环5-位的取代,无论是否同时伴有糖环2’,3’-双脱氧或2’,3’-双脱氢,或以环戊基、环戊烯基取代糖环.嘌呤核苷可通过改变糖环为环戊基或环戊烯基,或糖环为开链所取代,得到抗病毒药.已经试验有明显抗病毒作用的无环核苷类似物,如9-(2-羟乙氧基甲基)鸟嘌呤(无环鸟苷)等.胸苷酸合成酶
Structural modifications of natural nucleoside analogs are specific targets of certain key enzymes during viral replication These modifications include the substitution at the 5-position of the pyrimidine ring, whether accompanied by the sugar ring 2 ’, 3 ’- dideoxy or 2’, 3’-didehydrogenation, or cyclopentyl, cyclopentenyl substituted sugar ring purine nucleoside by changing the sugar ring is cyclopentyl or cyclopentenyl, or sugar ring For the open chain replaced to get antiviral drugs have been tested with obvious antiviral effects of acyclic nucleoside analogues, such as 9- (2-hydroxyethoxymethyl) guanine (acyclovir), etc. Chest Glycine synthase