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近年来,肿瘤病人的肾脏问题越来越受到重视,这是由于: ①许多肿瘤可侵犯肾脏,并成为主要预后因素之一; ②肾脏是某些抗癌药物的主要排泄器官,肾功能减退时抗癌药物之毒性可增强; ③某些抗肿瘤药物可损害肾脏。肿瘤患者的几个主要肾脏问题列于表1,本文主要综述抗肿瘤药物对肾脏的影响。抗肿瘤治疗的肾脏并发症肾脏并发症在抗肿瘤治疗中可能发生的肾脏并发症分为10类(见表2),其中有些是抗肿瘤治疗直接引起,如出血性膀胱炎、抗利尿激素分泌不当综合征(syndrome of inapropriate antidiuretic hormone,SIADH)等;另一些则通过某种间接因素引起,如高血钙,弥散性血管内
In recent years, the tumor patients’ kidney problems are getting more and more attention, which is due to: ① many tumors can invade the kidney and become one of the main prognostic factors; ② the kidney is the main excretion of certain anti-cancer drugs, renal dysfunction The toxicity of anti-cancer drugs can be enhanced; ③ Some anti-cancer drugs can damage the kidneys. Several major renal problems in cancer patients are listed in Table 1. This article reviews the effects of antineoplastic drugs on the kidneys. Kidney complications from anti-cancer treatment Kidney complications Kidney complications that may occur during anti-cancer treatment fall into 10 categories (see Table 2), some of which are directly caused by anti-cancer treatments such as hemorrhagic cystitis, antidiuretic hormone secretion Syndrome of inapropriate antidiuretic hormone (SIADH), etc .; others are caused by some indirect factors, such as hypercalcemia, disseminated intravascular