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目的 检测胃癌患者腹控冲洗液中T淋巴细胞及其亚群的含量,探讨其与胃癌临床病理因素和腹膜转移相关因素的关系。方法 采用流式细胞术(FCM)检测39例进展期胃癌、30例溃疡患者腹腔冲洗液中T淋巴细胞及其亚群的含量。结果 胃癌患者腹腔冲洗液中T细胞的含量与良性病变组的含量基本一致(P>0.05),且与肿瘤的分期无关,CD_8~+T细胞的含量高于良性病变组的含量,而CD_4~+T细胞含量低于良性病变组中的含量,但两者均无统计学差异(P>0.05)。结论 随着胃癌的进展和腹膜转移的发生,腹腔内的细胞免疫能力下降,CD_8~+T细胞含量的增加和CD_4~+/CD_8~+T细胞比值的下降是晚期肿瘤免疫抑制的一种特征表现。
Objective To detect the content of T-lymphocytes and its subpopulations in the gastric ulcers of patients with gastric cancer, and to explore the relationship between them and the clinicopathological factors of gastric cancer and related factors of peritoneal metastasis. Methods Flow cytometry (FCM) was used to detect the content of T lymphocytes and their subpopulations in 39 cases of advanced gastric cancer and 30 cases of ulcers. Results The content of T cells in the peritoneal lavage fluid of gastric cancer patients was basically the same as that in benign lesions (P>0.05), and it was not related to the stage of tumor. The content of CD_8~+ T cells was higher than that of benign lesions, but CD_4~ The content of +T cells was lower than that in benign lesions, but there was no significant difference between the two (P>0.05). Conclusion With the development of gastric cancer and the occurrence of peritoneal metastasis, the cellular immunity in the peritoneal cavity is decreased. The increase of CD_8~+T cell content and the decrease of the ratio of CD_4~+/CD_8~+ T cells is a characteristic of immunosuppression in advanced tumors. which performed.