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目的:评价泮托拉唑肠溶胶囊对胃食管反流病(GERD)的临床疗效及复发。方法:将87例经临床及内镜检查确诊的GERD患者,随机分为用泮托拉唑治疗组44例;用雷尼替丁作为对照组43例,比较其疗效及6月后复发率。结果:泮托拉唑钠肠溶胶囊治疗8周后反酸、烧心、胸痛、吞咽困难等症状缓解治愈30例,好转12例,无效2例,总有效率95%;雷尼替丁治疗8周后治愈23例,好转12例,无效8例总有效率81%;两组比较有显著差异性(P<0.05);6个月后治疗组治愈30例中复发19例占63%,对照组治愈23例中复发21例占91%;两组比较有显著差异性(P<0.05);复发病例按治疗组方案采取维持治疗都取得满意效果。结论:泮托拉唑肠溶胶囊对GERD有较好疗效值得临床推广应用。
Objective: To evaluate the clinical effect and recurrence of pantoprazole enteric-coated capsules on gastroesophageal reflux disease (GERD). Methods: Eighty-seven patients with GERD diagnosed by clinical and endoscopic examination were randomly divided into 44 cases treated with pantoprazole and 43 cases treated with ranitidine as control group. The curative effect and recurrence rate after 6 months were compared. Results: After treatment with pantoprazole sodium enteric-coated capsules for 8 weeks, 30 cases were relieved of symptoms such as acid reflux, heartburn, chest pain and dysphagia, 12 cases were improved, 2 cases were ineffective and the total effective rate was 95%. Ranitidine 8 Week 23 cases were cured, improved in 12 cases, 8 cases ineffective total effective rate of 81%; two groups were significantly different (P <0.05); 6 months after the treatment group cured 30 cases of recurrence in 19 cases accounted for 63% of the control In the group of 23 cases, 21 cases recurred, accounting for 91%. There was significant difference between the two groups (P <0.05). The recurrence cases were satisfied with the maintenance treatment according to the treatment group’s regimen. Conclusion: Pantoprazole enteric-coated capsules have a good effect on GERD and worthy of clinical application.