【摘 要】
：
目的:研究儿童性早熟发病危险因素及中医证型分布特点,探讨两者之间的相关性.方法:采用病例对照设计,纳入243例性早熟患儿为病例组,配比生长发育正常的儿童243例为对照组,采用调查问卷形式进行信息和临床资料收集,采用Logistic回归分析法探讨性早熟相关危险因素,并分析性早熟患儿中医证型分布特点.结果:在性早熟相关危险因素分析中,母亲初潮年龄≤12岁、有性早熟家族史、经常使用塑料制品包装或盛纳食物、使用洗发剂、亮灯睡觉、课业负担重、爱看情感类电视或小说、经常食用营养滋补品、经常食用动物性食品或高蛋白饮食、
【机 构】
：
上海中医药大学附属市中医医院,上海200071;复旦大学附属儿科医院,上海201102
论文部分内容阅读
目的:研究儿童性早熟发病危险因素及中医证型分布特点,探讨两者之间的相关性.方法:采用病例对照设计,纳入243例性早熟患儿为病例组,配比生长发育正常的儿童243例为对照组,采用调查问卷形式进行信息和临床资料收集,采用Logistic回归分析法探讨性早熟相关危险因素,并分析性早熟患儿中医证型分布特点.结果:在性早熟相关危险因素分析中,母亲初潮年龄≤12岁、有性早熟家族史、经常使用塑料制品包装或盛纳食物、使用洗发剂、亮灯睡觉、课业负担重、爱看情感类电视或小说、经常食用营养滋补品、经常食用动物性食品或高蛋白饮食、经常食用油炸类快餐、经常食用加工食品等是性早熟发病的高危因素(P＜0.05).在性早熟中医证型分析中,阴虚火旺证占42.0％、肝郁化火证占41.2％、痰湿壅滞证占14.0％、其他证型占2.9％.在危险因素与中医证型相关性中,肝郁化火型性早熟与看情感类电视或小说关系密切相关(P＜0.01),痰湿壅滞型性早熟与多食动物性食品或高蛋白饮食、多食油炸类快餐密切相关(P＜0.05).结论:性早熟危险因素较多,与母亲初潮年龄、家族遗传、饮食和生活习惯等相关;中医证型分布中阴虚火旺证与肝郁化火证比例相当,痰湿壅滞证比例较低;其中肝郁化火型性早熟与爱看情感类电视或小说关系密切,痰湿壅滞型性早熟与多食动物性食品或高蛋白饮食、多食油炸类快餐密切相关.
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