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越来越多的证据表明,一些细胞因子如白细胞介素-1(IL-1)和肿瘤坏死因子(TNF)能影响在体和离体垂体激素的释放。IL-1和TNF是自细胞介素-6(IL-6)合成的有效诱导剂。IL-6是由腺垂体内已被激活的单核细胞和滤泡星形细胞所产生的一种单核细胞因子。静脉注射IL-6能提高血浆ACTH水平,而且这种
There is growing evidence that some cytokines such as interleukin-1 (IL-1) and tumor necrosis factor (TNF) can affect the release of hormones in vivo and in vitro. IL-1 and TNF are potent inducers of cytokine-6 (IL-6) synthesis. IL-6 is a monocyte produced by monocytes and follicular astrocytes that have been activated in the pituitary gland. Intravenous IL-6 can increase plasma ACTH levels, and this